The Old Testament does not contain this exact phrase, but there are references that seem to match up. Ezekiel 30:3 points to “a time of doom for the nations” in connection with the Day of the Lord. Daniel’s series of visions deals with Gentile world powers and their role in God’s plan for the earth. Nebuchadnezzar’s image of gold, silver, bronze, iron, and clay (Daniel 2:31–45) represents successive Gentile kingdoms that will dominate until Christ returns and establishes His reign. Daniel’s vision of the four beasts (Daniel 7:1–27) likewise speaks of four kings, or nations, which will dominate for a time until Christ comes to rule forever. The vision of the ram and the goat (Daniel 8:1–26) gives more detail about these Gentile rulers and the time involved in their dominion. In each of these passages, the Gentiles have dominion over the world, including the Jewish people, for a time, but God will ultimately subdue them all and establish His own kingdom once and for all. Each prophecy culminates with a reference to Christ’s kingdom, so the “times” of these Gentile rulers would be all the years between the Babylonian Empire of Nebuchadnezzar and the glorious return of Christ to establish His kingdom. We are now living in “the times of the Gentiles,” that is, in the era of Gentile domination.
When we examine the book of Revelation, we find similar references to the time of Gentile dominion ending with the return of Christ. In Revelation 11:2, John indicates that Jerusalem will be under Gentile rule, even though the temple has been restored. The armies of the Beast are destroyed by the Lord in Revelation 19:17–19, just before the millennial reign of Christ is initiated.
Looking again at Luke 21:24, we see that Jesus mentions a time in which Jerusalem is under the dominion of Gentile authority. Nebuchadnezzar’s conquest of Jerusalem in 588 BC began that period, and it has continued through the present time. Romans 11:25 gives us a hint as to God’s purpose in the times of the Gentiles: the spread of the gospel throughout the whole world. The organization and inventions of the pagan world powers have actually aided the evangelism of the world. For example, in the first century, it was the widespread use of the Greek language and the network of Roman roads that allowed many people in far-off lands to hear the gospel.
One theme of Romans 11 is that, when the Jewish people rejected Christ, they were temporarily cut off from the blessings of a relationship with God. As a result, the gospel was given to the Gentiles, and they gladly received it. This partial hardening of heart for Israel doesn’t preclude individual Jews from being saved, but it prevents the nation from accepting Christ as Messiah until His plans are finished.
When the time is right,
God will restore the entire nation,
and they will come to faith in Him once again,
ending “the times of the Gentiles”
(Isaiah 17:7; 62:11–12; Romans 11:26).